Key Takeaways
- Calquence is a brand-name cancer tablet taken twice a day, so its list price adds up quickly over long-term treatment.
- What you actually pay depends on your coverage, how your plan shares the cost, and the help you qualify for.
- People who qualify may get help with the cost of Calquence, and a prescription advocacy service can manage that process for them.
Calquence has a list price of $271.73 per tablet, or $16,304 for a month’s supply of this twice-daily cancer tablet for chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Several options can reduce the Calquence cost, including no-cost manufacturer assistance for eligible patients, independent foundations, copay programs, and prescription advocacy services. They matter even for insured patients whose medication isn’t covered.
The Calquence Cost of Ongoing Cancer Treatment
Based on July 2026 pricing from AstraZeneca, the list price of Calquence is $271.73 per 100 mg tablet. That is the manufacturer’s price before insurance, pharmacy markups, or any assistance.
The usual dose is one tablet twice a day, as prescribed by your doctor, so a 30-day supply holds 60 tablets, and a full year holds 730.
| Supply | Tablets | List Price |
|---|---|---|
| 1 tablet | 1 | $271.73 |
| 30 days | 60 | $16,304 |
| 90 days | 180 | $48,911 |
| 1 year | 730 | $198,363 |
What Changes the Amount You Pay for Calquence
The list price is the same for everyone, but the amount each person pays is not. Four things make the most significant difference:
- Your insurance: Whether you have coverage, how your plan splits the cost with you, and whether it needs to approve Calquence before it pays.
- Your treatment plan: Some treatments pair Calquence with other cancer medicines, and a dose change from your doctor can change how many tablets you need.
- Where you fill it: Calquence may need to come from a specialty pharmacy, and each pharmacy sets its own price.
- The help you qualify for: Manufacturer programs, independent foundations, and advocacy services each have their own rules, and qualifying for one can bring the amount well below list price.
Is There a Cheaper Version of Calquence?
No generic version of Calquence is available in the U.S., so the brand-name tablet is the only form of acalabrutinib a pharmacy can fill. Without a generic on the market, there is no lower-cost version to push the price down the way generic competition usually does.
Other medicines in the same class, called BTK inhibitors, treat some of the same cancers. They are different drugs, not substitutes that a pharmacist can swap in, and whether another option fits your treatment is a decision for your doctor.
Affordability Options for Calquence
If your commercial insurance already covers Calquence, AstraZeneca’s copay program can lower your copay. A copay is the fixed amount you pay for a covered service after your deductible, according to HealthCare.gov. The program has savings limits and doesn’t apply to government-funded coverage.
Beyond that, three other paths can help, depending on your coverage and income.
Independent Foundations
Charitable foundations sometimes open funds for blood cancers that help insured patients with copays, coinsurance, and deductibles. Each foundation sets its own eligibility rules and decides what support it can give, so this help isn’t guaranteed. Your doctor’s office can tell you whether a foundation fund fits your situation.
AstraZeneca’s No-Cost Medication Program
AstraZeneca offers Calquence at no cost to patients without prescription coverage who meet its income guidelines. Approval depends on household income, insurance status, and the manufacturer’s current criteria. The application requires paperwork from both you and your prescriber.
Help With the Cost of Calquence
Prescription Hope works directly with AstraZeneca’s program on your behalf. The team handles the application, coordinates the forms your doctor needs to complete, tracks refills, and manages yearly renewals, all for a flat $70/month per medication. The medication is provided at no cost by the manufacturer, and the fee covers the advocacy service. Pre-qualification is at no cost, and you’re only charged if you’re approved.
Sorting out which path fits is where the process gets hard, because most of the rules are written around insurance categories.
How Prescription Hope Can Help With Calquence
Prescription Hope is a nationwide prescription advocacy service that has helped people access brand-name medications since 2006. It is not insurance, not a pharmacy, and not a coupon or discount card.
The team works with more than 180 pharmaceutical manufacturers, and it can offer help paying for Calquence to people without prescription coverage who meet the manufacturer’s income guidelines. After approval, your first delivery typically arrives in 2 to 4 weeks, usually as a 90-day supply, and advocates keep your prescription assistance going with each refill and renewal.
Eligibility depends on household income, the specific medication, and the manufacturer’s guidelines, so approval isn’t guaranteed in advance.
What Calquence Actually Costs and Where to Turn for Help
At list price, a year of Calquence comes to nearly $200,000, and that cost continues with every refill. Because treatment is ongoing, the option that matters most is the one that fits your coverage and keeps working through every renewal.
Prescription Hope can take on the paperwork of assistance programs for people who qualify, from the application to each yearly renewal, for a flat $70/month per medication. You can see if your medication qualifies for help with the cost of ongoing cancer treatment.
FAQs About the Cost of Calquence
Is the Price of Calquence the Same for CLL and Mantle Cell Lymphoma?
Yes, the price per 100 mg tablet is the same for both conditions. What you pay over time depends on the treatment plan your doctor prescribes, including how long you take Calquence and whether it’s combined with other medicines.
Is Prescription Hope a Legitimate Service?
Prescription Hope has helped patients access brand-name medications since 2006. It is BBB accredited and LegitScript approved, and patient reviews are public on Google and Trustpilot.
How Soon Will I Know If I Qualify for Help?
After you apply with Prescription Hope, the team lets you know within 48 business hours whether you’re eligible. From there, the team contacts your doctor for the prescription and any forms the manufacturer requires.
What If I Take Several Expensive Medications, Not Just Calquence?
Advocates can work on several medications at once, so separate applications, renewal dates, and refill schedules stay in one place. You don’t have to track each one on your own.
