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Home » Prescription and Medication » Motegrity vs Linzess – Similarities, Differences, Side Effects, Costs
Chronic idiopathic constipation (CIC) and irritable bowel syndrome (IBS) are two conditions that do not have a specific cause. Nearly 8 million people in the US seek medical attention for constipation every year. Therefore, certain medications can be prescribed to treat CIC and IBS.
So, in this article, we will discuss Motegrity vs Linzess and everything you need to know about these medicines. First, here is a quick explanation to get us started.
Motegrity vs Linzess: Motegrity and Linzess are two prescription drugs used to treat adults with CIC and IBS with constipation. Though both medicines offer the potential for the same treatment, they belong to different classes of drugs and may cause different side effects. The way you take each medication and the dosages also differ.
Now that you have the quick answer, let’s get into the specific details.
Motegrity is a serotonin-4 receptor agonist indicated for adults with chronic idiopathic constipation. Takeda manufactures this medication, and it received approval from the FDA in 2018.
The active ingredient in Motegrity, prucalopride, is released and absorbed after it is taken. It starts to target a certain receptor in the colon, which improves the natural movements of the colon. This helps with bowel movements.
Since Motegrity is considered a prokinetic medicine, it helps control one’s acid reflux. It also strengthens the lower esophageal sphincter and causes stomach contents to empty faster.
This medication may be suggested for off-label use to treat IBS with constipation.
Linzess is a guanylate cyclase-C agonist that is indicated for adults with CIC and IBS with constipation. This medication is manufactured by Ironwood Pharmaceuticals and received approval by the FDA in 2012 for IBS and 2017 for CIC.
Linzess is not a laxative and acts directly in the intestines. It works by calming pain-sensing nerves and by accelerating bowel movements.
The dosages and when one should take Motegrity and Linzess are different when compared to each other. Here is a breakdown of the dosages:
Both medicines are taken once daily, regardless of the dosage you have been prescribed.
It is recommended to take Linzess on an empty stomach at least 30 minutes before your first meal. Motegrity can be taken anytime with or without food but should be taken around the same time each day.
The most common side effects of Motegrity may include:
More serious but rare side effects of Motegrity may include changes in mood or behavior and suicidal thoughts. Patients should stop taking Motegrity right away if they begin to notice changes in their behavior. Notify your doctor immediately if you have worsening depression.
The most common side effects of Linzess may include:
Though diarrhea is the most common side effect, it can sometimes become very severe, requiring medical attention. Stop taking Linzess or Motegrity and call your doctor if diarrhea becomes severe.
Patients should notify their doctor of any side effect that bothers them or does not go away.
The safety information and warnings between Motegrity vs Linzess are similar but may differ slightly. Here is a breakdown of each medication’s safety information.
Important safety information for Motegrity:
Important safety information for Linzess:
Regardless of whether you are taking Motegrity or Linzess, you must talk to your doctor about any other medications you are taking. This includes other prescription drugs, over-the-counter medicines, vitamins, or herbal supplements.
The out-of-pocket cost for Motegrity 1 mg tablets is about $465 for 30 tablets.
The out-of-pocket cost for Linzess 72 mcg capsules is about $474 for 30 capsules.
Through Prescription Hope, you can pay just $50 a month each of these medications.
The effectiveness of Motegrity and Linzess will vary from person to person. Each patient will have different needs and respond differently to the medicines prescribed. Therefore, patients must listen to their doctor’s instructions and advice when getting prescribed medications.
Based on patient reviews, Motegrity was more effective for many over Linzess. It can be taken with or without food, which many find beneficial over Linzess. However, as mentioned before, each patient will respond differently. So, where some find Motegrity more effective, you may experience worse side effects with Motegrity than Linzess. So, Linzess might be your preferred medicine when comparing these two.
We hope this has given you better insight into Motegrity vs Linzess. Always consult your doctor for questions regarding your specific condition. If you start to have severe side effects or believe the medicine you have been prescribed is not working, then consult your doctor right away.
If you are struggling to afford your medications, then Prescription Hope can help. We work directly with pharmaceutical manufacturers to provide patients with the medicine they need at a set, affordable cost. Enroll with us and start paying just $50 a month for each of your prescribed medicines.
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